Research Topics and Expertise

The department focuses on design, chemo- or biosynthesis of compounds with biological or (potential) medicinal applications and interaction with their receptors. Insights thus obtained could lead to new bio-active compounds, new approaches for the treatment of still incurable diseases and new approaches to unsatisfactory treatments. We are interested in answering questions related to understanding as well as influencing peptide-protein, carbohydrate-protein and protein-protein interactions that underlie e.g. infection, immunological and neurological disorders. Especially modified peptides and peptidomimetics as well as carbohydrates are synthesized and studied.

Synthetic Medicinal Chemistry
- Specialized in the synthesis of peptides, peptidomimetics and carbohydrates as bio-active molecules for study and modulation of disease related processes on a molecular level.


ABC expertise


Biogenic Medicinal Chemistry
- Specialized activity-guided isolation of bioactive components from plants.

Biophysical and Computational Medicinal Chemistry
- Specialized in measurements of structural properties of molecules, binding affinities as
  well as thermo dynamical aspects of ligand-receptor interactions.
- Specialized in Computer-Aided Molecular Design procedures as a part of "modeling-guided synthesis".

Research topics include:
(1) Design and synthesis of high-affinity multivalent carbohydrate ligands.
(2) Molecular recognition of phosphopeptides and peptidomimetics by SH2 domains.
(3) Peptide-peptide and protein-protein aggregation related to formation of amyloid fibrils and self-assembly.
(4) Covalent control of shape and folding in peptides among others by Ring Closing Metathesis.
(5) Synthetic receptors and synthetic antibodies.
(6) Development of molecular probes for proteomics purposes.

Our Publications from 2000 up to 2009

* Covers of journals highlighting our papers

* Dissertations